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Annals of Internal Medicine, 149 (9), 601611

Masashi Murakami, Dr

They are defined by impairments in communication and social interaction along with restrictive and repetitive behaviors ( Autism spectrum disorder has been recently estimated to affect 1 out of 68 individuals in the United States ( A great majority of ASD research has concentrated on genetic causes of ASD ( de novo mutations, thereby pointing to acquired mutations and/or mutations secondary to errors in DNA maintenance rather than inherited genetic syndromes ( Recent studies have suggested that ASD is associated with impairments in basic physiological processes such as redox ( Identifying the metabolic or physiological abnormalities associated with ASD is important, as treatments for such abnormalities may be possible