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Proline, as a non-proteinogenic amino acid, is well-known for its roles in plant adaptation to abiotic stresses, including heat stress, in various plant species and functions during osmotic adjustment for cellular turgor maintenance, the maintenance of membrane stability, and antioxidant protection (Hayat et al

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Topiramate additionally requires precaution in women of childbearing potential as topiramate is associated with oral clefts if used during early pregnancy