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doi: 10.1007/s11845-020-02388-z

21 Because chronic pain is the leading cause of disability in U.S

It also can be used to oppose maladaptive changes in body composition such as reduced lean body mass (muscle), increased total and visceral fat, and decreased bone mass resulting from low or inadequate concentrations of serum GH and insulin-like growth factor-1 (IGF-1)