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doi: 10.1016/j.intimp.2020.107029 49

Garca-Daz L, Coserria F, Antiolo G

An increase in glutamine synthetase abolishes the production of -KG from glutaminolysis, as a result, an inhibition of mTORC1 is observed as well as an enhancement of autophagy, which is imperative for cancer cell survival (154, 175)