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The reactivity and functional consequences of nitrosylation at a variety of nucleophilic centers in biological molecules represent another intervention accerssible by GSH therapy

However, if saturated fatty acids accumulate in excess in cells, they become toxic and induce the generation of ROS, endoplasmic reticulum stress and NLRP3 inflammasome activation, which are all associated with a pro-inflammatory macrophage phenotype (Legrand-Poels et al., 2014)

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Melatonin, secreted by the pineal gland in response to darkness, plays a key role in maintaining circadian homeostasis and exhibits broad oncostatic properties 19

The slides were then incubated with horse anti-rabbit IgG (BA1100, Vector) for 30 min at room temperature, followed by the VECTASTAIN Elite ABC-HRP kit, peroxidase (PK6100, Vector) for 30 min at room temperature