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221 Upon exposure to cellular stress, decreased MDM2 levels and increased p53 levels induce a consistent interaction between p53 and GSK3, possibly promoting tau hyperphosphorylation

Michnovicz JJ, Adlercreutz H, Bradlow HL

Among the kynurenines, only the basal concentration of HK increases in plasma in vitamin B6-deficient subjects, which probably reflects that its removal but not formation involve PLP-dependent enzymes (Figure 2)

Although there have been some recent mechanism-related studies, relevant clinical research is still lacking at present

Morshedzadeh N, Rahimlou M, Shahrokh S, Karimi S, Mirmiran P, Zali MR