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-Klotho abolished the interaction between Wnt ligands and the receptors and then inhibited the activation of Wnt/-catenin signaling

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This pigmentation is considered a side effect rather than a therapeutic benefit because: It's unpredictable in location and intensity It's focal (patchy) rather than uniform It isn't UV-protective tanning It's generally unwanted by patients It can be cosmetically concerning In most cases, these pigmentation changes resolved after discontinuing PT-141