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Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth

Unlike other compartments, the ER lacks the reductase needed to convert GSSG back into GSH, making GSSG export vital for maintaining the GSH/GSSG balance

Furthermore, at neutral pH, glucose catabolism results in the accumulation of acetate, which is not further catabolized until glucose is exhausted

Additionally, SF demonstrated protective effects in rodent models of vascular cognitive impairment induced by ischemia at 56.4 mol/kg twice a week (112), subarachnoid hemorrhage at 282 mol/kg every 24 h (113), and intracerebral hemorrhage at 5.64 mol/kg twice a day (114), with upregulation of Nrf2 and reduced inflammation reported in the latter two