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Name: how many times a day should i take l carnitine What Is L-Carnitine? | L-Carnitine Benefits, Dosage & When To take? Acetyl L-Carnitine
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Antiepileptic medicines such as phenytoin or phenobarbital: Long-term use may affect vitamin B metabolism and increase the risk of deficiency

Also, the usual first line diuretic, furosemide, is known to lose its effectiveness eventually, as the dog's body tends to resist the effects of the drug (diuretic resistance)