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For example, Icarin was confirmed to inhibit ECM degradation and ferroptosis in chondrocytes, thereby alleviating articular cartilage damage in OA rats by restoring SLC7A11 and GPX4 expression (Xiao et al., 2024)

Key active ingredients include Sodium Bicarbonate, BPC-157, and Hyaluronic Acid

465,466 This activation is predominantly mediated through the disruption of the Kelch-like ECH-associated protein 1 (KEAP1) - NRF2 interaction (oxidation of KEAP1 Cys151, Cys273, and Cys288), 29 facilitating the translocation of NRF2 into the nucleus

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L-carnitine alleviates synovitis in knee osteoarthritis by regulating lipid accumulation and mitochondrial function through the AMPK-ACC-CPT1 signaling pathway