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Furthermore, no clinical trials of ferroptosis-targeted monotherapies or combinations exist for RCC, largely due to insufficient preclinical validation in patient-derived models [e.g., patient-derived xenografts (PDXs) and organoids]

Intriguingly, the R groups exhibited a significant elevation in the plasma ATP compared to the HC and R groups ( Figure 6M )

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We only included those post-LT pts who did not require re-LT, were stable clinically & did not have recent rejection episodes or infections

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