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Inhibition of PL and IL projection neurons prevents the expression of fear behaviors (Do-Monte et al., 2015) and the retention of fear extinction memories (do-Monte et al., 2015), respectively

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Moreover, it can increase the levels of GSH within the cells, which chelate and eliminate a wide range of toxins, particularly toxic metals [2,68]

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To ask how -KG insufficiency depletes the cytosolic NADPH pool, we first confirmed that cytosolic NADPH-producing enzymes ME1 and IDH1 are essential for cell survival during energy stress, as previously reported 26,31 , because knockdown of either gene sensitized Huh7 and H1299 cells to glucose starvation (Supplementary Fig