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Notably, experimental evidence demonstrates that DAB2IP linearly inhibits both the JAK2/STAT and PI3K/Akt pathways, an integrated model further proposes the existence of significant crosstalk between these pathways, potentially forming a feed-forward loop that amplifies the dysfunction of VSMCs (33)

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DOI: 10.1007/978-3-319-04990-8 97

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In many cases, the best approach is a combination therapy, where you might use a topical treatment at home to complement your in-office PRP sessions