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Antioxidant therapy: current status and future prospects

[1] People who regularly take medications that suppress stomach acid for conditions like gastroesophageal reflux disease (GERD) or peptic ulcer diseasesuch as proton-pump inhibitors, H2 blockers, or other antacidsmay have difficulty absorbing vitamin B12 from food

Dosage ranges reported in literature: Conservative start: 200 to 250 mcg daily, split into two doses of 100 to 125 mcg administered 12 hours apart Standard protocol: 300 to 400 mcg daily, considered the optimal range for most healing applications based on clinical observations Acute injury protocol: 400 to 500 mcg daily, split into two to three doses throughout the day Weight-based considerations: Under 150 pounds: 200 to 300 mcg daily 150 to 200 pounds: 300 to 400 mcg daily Over 200 pounds: 400 to 500 mcg daily Cycle length typically runs four to eight weeks, with some practitioners suggesting six to twelve weeks followed by a four to eight week break

Two-Participant Pilot Publication A 2025 publication reported an intravenous pilot involving two adults

[2] Obeid R, et al