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The basic mechanism involves the tissue injury which activates NF-B, dissociates IB as a result of which the NF-B enters the cell nucleus and activate the DNA to enhance the inflammatory cytokines [20]

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A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of TH2 cells

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This peptide may be a central factor in immunity to TPO(18.1)

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Lactate also acts on these immune cells epigenetically by increasing H3K9 acetylation in macrophages at genes like ARG1 and Retnla, reinforcing M2 gene expression and locking TAMs into an M2 polarized state (61)

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10.1002/fsn3.4105 [DOI] [PMC free article] [PubMed] [Google Scholar] Hsiao W

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