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But half-life and duration of effect are different things

The divergent structures of the BBB in rodents and humans complicate the extrapolation of preclinical data to humans (Hoshi et al., 2013)

In the context of disrupted circadian rhythms, the use of naturalistic lighting optimizes light exposure similar to solar time, allowing for resynchronization of the internal biological clock to the natural light dark cycle (West et al., 2019)

Preclinical studies demonstrate biologic activity relevant to tissue repair, supporting biologic plausibility but not clinical effectiveness

Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis