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In addition, coumaric acid and caffeic acid prevents heart disease, liver disease, stomach cancer, and renal toxicity and immune system regulation through cholesterol modulation

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Therefore, the aim of this review is to describe the molecular mechanisms involved in the redox signaling influence on mitochondrial and ER homeostasis, focusing on lipid metabolism and -oxidation, mitochondrial biogenesis, inflammations, ER stress and calcium homeostasis, as well as the effects of these alteration in the genesis and development of renal disease, with emphasis in acute kidney injury (AKI) and chronic kidney disease (CKD)

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Notably, co-encapsulation of ATRA and ATO within albumin-based nanoparticles has not yet been investigated as a strategy for spatiotemporal and simultaneous multi-domain PIN1 inhibition