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2017;78(5):e555e558

In ALS, reduced astrocytic EAAT2 levels and altered microRNA regulation (e.g., increased miR-218 and decreased miR-124a) result in the accumulation of EAAT2-derived toxic species, accumulation of glutamate, and motor neuron degeneration

The prooxidant oxidative stress imbalance needs an antioxidant system able to balance it and the principal role in antioxidant defense is carried out by antioxidant enzymes, with the paramount involvement of small-molecule antioxidant compounds like GSH

Using forceps, the stimulus was applied to the rats hind limb by momentarily pinching the areas innervated by the tibial, fibular, and sural nerves

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