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Type 1 diabetes is primarily caused by destruction of insulin-producing pancreatic beta cells by autoimmune disease or rarely other causes such as trauma

Aronica SM, Kraus WL, Katzenellenbogen BS

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Ubiquitinproteasome system The ubiquitinproteasome system (UPS) is responsible for targeted protein degradation

Another study focusing on Wnt signaling in mononuclear cells and fibroblasts found that the promoters of DKK1 (Dickkopf WNT signaling pathway inhibitor 1) and SFRP1 (secreted frizzled-related protein 1) were hypermethylated in SSc