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However, Chu found that activation of p53 alone did not significantly downregulate GSH/GSSG ratio, glutathione levels, and GPX4 activity in human cancer cells

10.1016/j.neulet.2013.03.059 Summary Keywords suicidal ideation, suicide attempt, suicide, suicidal behaviour, oxidative stress, biomarkers, DNA damage, bipolar disorder Citation Loo JL, Mohamad Kamal NA, Goon JA, Ahmad Damanhuri H, Tan JAC, Abdul Murad NA, Shah SA, Sulaiman SA, Fazry S, Sharip S, Mohamed Saini S, Gunasekaran G, Maniam T, A

doi: 10.1101/mcs.a006081 72

Research conducted during the past two decades has shown glutathione helps boost immunity, improve strength and physical performance, and reduces the risk of age-related diseases

We found that the aberrant accumulation of fumarate leads to the persistent depletion of GSH via the formation of the adduct succinicGSH