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The first step of this pathway involves the production of a highly toxic substance, N-acetyl-p-benzoquinone imine (NAPQI)

Med Gas Res 6:7984 Huang P, Chen S, Wang Y, Liu J, Yao Q, Huang Y, Li H, Zhu M, Wang S, Li L, Tang C, Tao Y, Yang G, Du J, Jin H (2015) Down-regulated CBS/H 2 S pathway is involved in high-salt-induced hypertension in Dahl rats

Additionally, some studies have indicated that certain medications for underlying conditions, commonly used in older adults, can lead to nutrient deficiencies

Glutathione is a key player in Phase II of this process

Carcinogenesis 24(12):19031911 Bergstrom P, Andersson HC, Gao Y, Karlsson JO, Nodin C, Anderson MF et al (2011) Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage