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Curcumin enhances the activity of intrinsic antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT), while decreasing levels of malondialdehyde (MDA), a biomarker of lipid peroxidation

This difference between CYP1A1 and CYP1A2/1B1 needs to be further investigated

Why the Glutathione Index Is the Best Indicator of Brain Oxidative Stress The GSH/GSSG ratio reflects the activity of the enzyme glutathione reductase which is responsible for the transformation of GSSG (used, oxidised) to GSH (the reduced or fully loaded form that acts as a radical scavenger)

Rhabdomyolysis may present as myopathy (myalgia, myasthenia, muscle cramps, muscle weakness, muscle tenderness, fatigue), elevations in creatinine phosphokinase (CPK), or renal dysfunction (renal tubular obstruction)