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Furthermore, excessive copper in chicken liver cells leads to varying degrees of nuclear membrane damage, mitochondrial swelling and vacuolization, upregulation of caspase-3, cytochrome c, Bax, and Bak1 expression, downregulation of Bcl2, and increased expression of P53, indicating that copper may induce cell apoptosis by damaging mitochondria (136)

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therefore, findings in the subgroup receiving both drugs need to be interpreted cautiously, Dr

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