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ATRA is now widely used in preclinical and clinical studies and has shown great anticancer potential in phase II and III clinical trials in patients with various cancers [180]

Leave-one-study-out analyses (Supplementary Table 1) revealed some variability in p-values ( P = 3.1 10 7 7.4 10 9 for rs2714700 and P = 5.6 10 9 3.9 10 6 for rs1862416), likely due to fluctuating statistical power given the significant correlation between N (sample size) and p-value across iterations: r = 0.65, P = 8.6 10 5

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