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The antioxidant activity of GSH intermediated via thiol (-SH) of its cysteine residue upon its interaction with ROS or electrophiles and the GSH oxidized to GSSG (oxidized Glutathione), the GSSG will reduce to GSH by Glutathione reductase (GR), the activity of GR is therefore very important to keep the antioxidant power of mammalian cells, while GSH/GSSG ratio is an indicator for redox balance in the cell

The change in the DNA causes the enzyme to be more thermolabile, which means that the enzyme loses its activity when exposed to moderate heat

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Tabernor J, Grothey A, Van Cutsem E, Yaeger R, Harpreet W, Yoshino T, Desai J, Ciardiello F, Loupakis F, Hong YS, Steeghs N, Guren T, Arkenau H, Garcia-Alfonsi P, Elez E, Gollerkeri A, Maharry K, Christy-Bittel J, S|| K