Alteration of intracellular structure and function of glyceraldehyde-3-phosphate dehydrogenase: a common phenotype of neurodegenerative disorders
LIPID DISORDERS / STATE OF THE ART PAPER The effects of statins on the function and differentiation of blood cells , More details Hide details 1 Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences (BUMS), Birjand, Iran 2 Department of Immunology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran 3 Department of Molecular Medicine, Birjand University of Medical Sciences, Birjand, Iran 4 Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 5 School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, United Kingdom 6 Department of Hypertension, WAM University Hospital, Medical University of Lodz, Lodz, Poland 7 Department of Cardiology and Adult Congenital Heart Diseases, Polish Mothers Memorial Hospital Research Institute (PMMHRI), Lodz, Poland 8 Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran 9 Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran 10 School of Medicine, The University of Western Australia, Perth, Australia 11 Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Submission date: 2022-12-09 Final revision date: 2022-12-23 Acceptance date: 2022-12-25 Online publication date: 2022-12-25 Publication date: 2023-09-01 Arch Med Sci 2023;19(5):1314-1326 KEYWORDS TOPICS ABSTRACT Statins are inhibitors of -hydroxy -methylglutaryl-CoA (HMG-CoA) reductase (HMGCR)
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The side cleft between the short TM3 from the minor TM domain and the highly curved TM7 from the major TM domain appears as a hole with a diameter of ca
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