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These results demonstrate that inhibiting ferroptosis, rather than activating the AMPK pathway, is the primary mechanism of action of metformin against IIRI

After systematically dissecting the molecule into fragments, they found that the C-terminus (amino acids 177 to 191) preserves the lipolytic effect without the other GH functions

Acknowledgement ABCD Europe gratefully acknowledges the support of Boehringer Ingelheim (the founding sponsor of the ABCD), MSD Animal Health, Vtoquinol and Virbac