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4) Blood Disorders Certain conditions affecting blood and bone marrow including some leukaemias and myeloproliferative disorders such as polycythaemia vera can cause elevated B12 due to increased production of B12binding proteins by white blood cells

SAM is produced within the body and obtains its required methyl group from methylcobalamin underlining the importance of methylcobalamin as a central supplier of methyl groups

When caloric intake is low, your body needs vitamin B6 to help convert stored carbohydrate or other nutrients to glucose to maintain normal blood sugar levels