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This suggests that intracellular fluctuations of NAM could influence sirtuin activity

10.1016/j.bbrc.2022.03.026 266 ZhangJ.GaoR.-F.LiJ.YuK.-d.BiK.-X

Impact of gsp oncogene on the expression of genes coding for Gsalpha, Pit-1, Gi2alpha, and somatostatin receptor 2 in human somatotroph adenomas: involvement in octreotide sensitivity

doi: 10.1126/science.276.5317.1420 15 BlumenthalA.KobayashiT.PieriniL

Hemin acts as a potent inductor of HO-1, which promotes the healing process through the reduction of oxidative stress as is evident by the diminished level of lipid peroxidation, and elevated levels of various antioxidant defense mechanisms, including GSH, SOD, GPx, and catalase [55, 120]