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Bacopasaponin C: critical evaluation of anti-leishmanial properties in various delivery modes

doi: 10.1038/nrd795 97 WangJLobergRTaichmanRS

SOD2) ( 2 O 2 , producing H 2 O and O 2 ( Intrinsic apoptosis is a form of programed cell death (RCD) initiated by a variety of microenvironmental perturbations, including (but not limited to) growth factor withdrawal, DNA damage, endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) overload, replication stress, microtubular alterations, and mitotic defects ( Intrinsic apoptosis (type I cell death) ( Bcl-2 family proteins are subdivided into three groups on the basis of their pro- or anti-apoptotic action and Bcl-2 homology (BH) domains ( The mechanisms for the activation of pro-apoptotic Bcl-2 family members, such as Bax and Bad, have been well-studied

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