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285 Mitochondrial respiration involves glycolysis in the cytoplasm, followed by the TCA (Krebs) cycle in the mitochondrial matrix (Fig

Cysteine, derived from cystine, is a rate-limiting substrate for the synthesis of the antioxidant GSH ( Studies have shown that inhibiting system X c - using erastin and sulfasalazine in cancer cells cultivated in covered dishes results in a unique form of iron-dependent cell death known as ferroptosis ( c - , impeding GSH absorption