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Optineurin is the most important adapter for the recruitment of phagophores to the mitochondria (Moore and Holzbaur, 2016)

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Additionally, in patients with amyotrophic lateral sclerosis (ALS), VNS might ameliorate oxidative stress and mitochondrial dysfunction, thereby reducing motor neuron degeneration, increasing neuronal survival, and improving quality of life (110)

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The consistent and strongest conformation regarding the protective effect of large consumption of carotene-rich food comes from studies of the esophagus and lung cancer (Patel et al., 2018)