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Additional information Peer review information Nature Communications thanks Maggie Levy and Philippe Simoneau for their contribution to the peer review of this work

Cytokines play important role in disease pathogenesis as well as disease severity, so an association of TLR polymorphism and cytokines production would help in vaccine designing as well as designing tools for control and elimination of malaria

Future research should focus on developing non-invasive or minimally invasive sampling methods to improve sample diversity and conduct large multicenter cohort studies to enhance result generalizability

they are made into teas, syrups and jellies, and used to make oils for the complexion

Dietary Changes : Some families report benefits from gluten-free or casein-free diets, which may help reduce behavioral challenges