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Lancet 378(9795):10271037 Martnez G, Mijares MR, De Sanctis JB (2019) Effects of flavonoids and its derivatives on immune cell responses

During bacterial or virus infection of the respiratory tract, natural killer cells (NK cells) and DCs of lung tissue secrete IL-13 to activate the signal transducer and activator of transcription (STAT) 6 pathway, which leads to goblet cell hyperplasia, smooth muscle hyper-responsiveness, and airway remodeling (Horvat et al., 2010