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Several clinical trials have assessed the efficacy of systemic delivery of recombinant IGF-I in patients who could benefit from strength gains, summarized in Table 1

Bianchi, Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis

Nrf2 regulates important genes such as heme-oxygenase 1(HO-1), glutathione S-transferase (GST), glutathione reductase (GR), glutamate-cysteine ligase subunits (GCLc and GCLm), NAD(P)H quinone oxidoreductase-1 (NQO1), and thioredoxins (TrxR1), among others