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The significance of this weak binding to IGFBPs is that the compound can exert more pharmacological action in animal subjects since IGFBPs decrease the pharmacological activity of hormones that are strongly bound to it

Science 324:10681071 Piskurewicz U, Jikumaru Y, Kinoshita N, Nambara E, Kamiya Y, Lopez-Molina L (2008) The gibberellic acid signaling repressor RGL2 inhibits Arabidopsis seed germination by stimulating abscisic acid synthesis and ABI5 activity

An interesting observation in the current study is the notion that coated membrane without donepezil drug action could have an ameliorating effect at multiple levels of assays and was of profound behavioral reflection in reducing symptoms of AD