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According to the American Lung Associations analysis of CDC data, smoking rates among adults plummeted from 42.6% in 1965 to 11.6% in 2022a 73% drop

When compared to non-smokers, these smokers had 15% higher total testosterone and 13% higher free testosterone

During this period, the number of Year 10 students who smoked regularly was essentially unchanged meaning the rise in student vaping had negligible effect on reducing smoking rates

A recent oral transcriptome analysis in by RNA-Seq revealed cancer as the top disease associated with dysregulated genes in e-cig users 39

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