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WE-EF-BRA-05: Experimental Design for High-Throughput In-Vitro RBE Measurements Using Protons, Helium and Carbon Ions

Furthermore, MDA can directly interact with DNA, causing strand breaks and base modifications, thereby adversely affecting sperm DNA integrity and reducing fertilization potential (115, 116)

10.1046/j.0953-816x.2001.01691.x Eur

Notably, the accumulation of genetic mutations (e.g., point mutations, inversions, translocations, deletions, and polyploidy) drives the malignant transformation of cancer cells and facilitates the acquisition of cancer-specific hallmarks, including cell immortality, apoptosis inhibition, drug resistance, angiogenesis, invasiveness, and the activation of metastatic processes [3,4,5,6]