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Twenty-four hours after the last injection, adolescent mice pretreated with ALP (0.5, 1.0 mg/kg) showed a preference for environments previously paired with 2.5 mg/kg MOR, a subthreshold dose that had no significant effects in the VEH-pretreated mice

In in vivo experiments, Quercetin could also regulate the SIRT1/AMPK pathway to reduce oxidative stress and inflammatory damage in mouse lungs, thus alleviating septic lung injury

doi: 10.1152/physrev.00030.2013 52

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90 In the UPS, the E3 ligase is considered an important component of the ubiquitin binding system and plays a role in substrate-specific recognition