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Polyunsaturated fatty acids (PUFAs) have been shown to reduce hepatic triglyceride accumulation, while diets high in the n-6/n-3 PUFA ratio and low in total PUFA content are linked to the development of fatty liver and other chronic metabolic disorders [75, 76]

Conversely, supplementation with exogenous -KG or its analogs enhances mTORC1 activation in nave CD4+ T cells, upregulating the transcription factor T-bet and driving Th1 differentiation (71)