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this superiority may be attributed to the evasion of first-pass metabolism associated with the oral administration of Plendil, in addition to the enhanced drug permeation in the nano-spanlastic-loaded wafer compared to Plendil, as evidenced by permeation and CLSM studies

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any kind of multimerization domain can be used, including any kind of cell, polymer, protein or other molecular structure, or particles and solid supports

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12 Alvarez-Rivera et al set out to create ALA formulations based on micelles with the goal of boosting apparent solubility by more than ten times when compared to commercially available eye drops