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Experiment 1: Kinase Activity on a Wild-Type NHR-49 Peptide to test linear range: The first experiment assessed the activity of three recombinant kinases, CSNK1A1 (Cat

3.3 Interventions to regulate mitophagy Mitophagy, a key quality control mechanism, plays a dual role in maintaining chondrocyte homeostasis: moderate activation eliminates dysfunctional mitochondria and interrupts the ROS-inflammation-cell death cycle, whereas defective or excessive autophagy accelerates OA progression

2019;317:C1161c71