Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4)-MMAE Size:1mg Product Name Thalidomide-O-acetamido-C5-OH Synonyms Thalidomide-4'-O-acetamido-C5-OH

Product Name Thalidomide-O-acetamido-C5-OH Synonyms Thalidomide-4'-O-acetamido-C5-OH CAS Number n/a Related CAS Molecular Formula C20H23N3O7 Molecular Weight 417

such as amino acids

the resulting compound loses its ability to form this covalent bond

1-dimethylethyl ester CAS Number 874831-92-2 Related CAS Molecular Formula C16H31N3O2 Molecular Weight 297

664 SMILES NCCOCCOCCOCCNC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4)-MMAE Size:1mg Product Name Thalidomide-O-acetamido-C5-OH Synonyms Thalidomide-4'-O-acetamido-C5-OHSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly