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YH677 inhibited epithelial mesenchymal transformation (EMT) and stem cell marker expression in a dose-dependent manner (134)

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For treatment, ion-interference therapy (IIT), which uses bioactive ions (such as Cu 2+ for glutathione (GSH) depletion and Ca 2+ for oxidative stress-mediated apoptosis) to reverse the distribution state of ions in cancer cells by changing the physicochemical properties and biological functions at the cellular level 36,37,38 , is effectively used for regulating oxidative stress-mediated apoptosis pathways

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