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KRAS G12C-Mutant Non-Small Cell Lung Cancer: Biology, Developmental Therapeutics, and Molecular Testing

Readers are referred to the Lipid oxidative damage under blue light section for details on protein modifications caused by lipid peroxidation byproducts

A 1987 study on mice determined oral glutathione to be nontoxic,27 and a 2017 toxicity study (also on mice) found that glutathione's LD (the amount of a substance needed to kill 50% of all test animals in one dose) was 5g/kg.6 An equivalent toxic dose for an 80kg human would be 32.5g, which is more than 32 times the highest amounts used in clinical studies

doi: 10.1056/NEJMra1905136 125

Contents Historical background Main function Sites of the pentose phosphate pathway Oxidative phase of the pentose phosphate pathway Non-oxidative phase of the pentose phosphate pathway The cells need for NADPH, ribose 5-phosphate, and ATP References Historical background The first evidence of the pentose phosphate pathway emerged in the 1930s through the work of Otto Warburg , who received the Nobel Prize in Physiology or Medicine in 1931 for his work on cellular metabolism and respiratory enzymes