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They are different expressions of the same biological reality: the body's ability to heal, protect, and renew itself declines across the decades in ways that accelerate disease and compress the years of genuine vitality

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Among them, the cytosolic enzyme nicotinamide N-methyltransferase (NNMT) has been newly discovered to regulate the levels of nicotinamide precursors required for NAD+ biosynthesis, and therefore plays a crucial role in regulating the NAD+ salvage pathway and cellular metabolism