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10.1095/biolreprod61.2.541 59 SunD.TongW.HanS.WuM.LiP.LiY.et al (2025)

Anatomical basis of tolerance and immunity to intestinal antigens

Intracellular glutathione peroxidase 4 (GPX4) uses reduced glutathione (GSH), an antioxidant, to reduce lipid peroxides generated by reactive oxygen species (ROS).* However, when lipid peroxides accumulate due to GPX4 disruption or GSH depletion, ferroptosis is triggered