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Advanced practice providers are on the front lines of treatment and are best positioned to relate directly with the patients and help them mitigate or manage their AEs, which will importantly reduce the need for dose reduction or discontinuation (see Appendices A and B for fictional scenarios illustrating the management of patients with CCA)

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2 CKD and renal fibrosis Renal fibrosis is a hallmark feature of the progression of CKD to ESKD, characterized by tubular atrophy, chronic interstitial inflammation, fibrosis, glomerulosclerosis, and vascular rarefaction (Yuan et al., 2022)

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