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Then literatures reported the Ala177Val mutation has no influence on the kinetic parameters of bacterial MTHFR, but rather reduces enzyme stability and affinity for cofactor, and thus increases the tendency to form inactive enzyme via flavin dissociation, compared to the wild-type enzyme 27

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Some researchers report a subtle energy increase likely from increased fatty acid availability

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Combined with biomarkers and provider guidance, this may support more informed conversations about treatments like GHK-Cu