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3.4 Methodological quality of included reviews The methodological quality of the included reviews was assessed using the AMSTAR-2 tool (Supplementary Table 2)

Most importantly, growth hormone stimulates the production of insulin-like growth factor-1 (IGF-1), a powerful mediator of tissue growth and repair

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These results highlight the therapeutic potential of DSIP-CBBBP in ameliorating neuronal loss associated with insomnia, suggesting promising avenues for developing treatments for sleep-related neurological impairments